diff --git a/mypy/subtypes.py b/mypy/subtypes.py
index 5733797326e8..f215ef75733e 100644
--- a/mypy/subtypes.py
+++ b/mypy/subtypes.py
@@ -521,6 +521,10 @@ def visit_instance(self, left: Instance) -> bool:
                             or mapped.type.has_type_var_tuple_type
                         ):
                             return True
+                    # A NamedTuple Instance is a subtype of its own TupleType
+                    # representation (they are two views of the same type).
+                    if mapped.type.is_named_tuple and mapped.type is right.partial_fallback.type:
+                        return True
             return False
         if isinstance(right, TypeVarTupleType):
             # tuple[Any, ...] is like Any in the world of tuples (see special case above).